产前物质暴露和早期逆境对寄养儿童在心理社会应激源期间下丘脑-垂体-肾上腺（HPA）轴反应性的累积影响。
Cumulative Effects of Prenatal Substance Exposure and Early Adversity on Foster Children's HPA Axis Reactivity During a Psychosocial Stressor.
作者信息
Fisher Philip A, Kim Hyoun K, Bruce Jacqueline, Pears Katherine C
机构信息
Oregon Social Learning Center and University of Oregon.
出版信息
Int J Behav Dev. 2012 Jan 1;36(1):29-35. doi: 10.1177/0165025411406863. Epub 2011 Jun 17.
Abstract
Dysregulated hypothalamic-pituitary-adrenocortical (HPA) axis stress response has been reported among individuals with prenatal substance exposure and those with early adversity. However, few researchers have examined the combined effects of these risk factors. Patterns of HPA reactivity among maltreated foster children with and without prenatal substance exposure (N = 53; ages 9-12 years) were examined using the Trier Social Stress Test for Children. Area under the curve with respect to increase (AUC(I)) analyses revealed that prenatal substance exposure or physical abuse significantly increased the likelihood of a negative AUC(I) (i.e., little or no HPA reactivity). Among children with prenatal substance exposure and physical abuse, 85% exhibited a negative AUC(I). The results underscore the importance of addressing this combined risk.
摘要
据报道，产前接触物质的个体和经历早期逆境的个体存在下丘脑-垂体-肾上腺皮质（HPA）轴应激反应失调的情况。然而，很少有研究人员考察过这些风险因素的综合影响。使用儿童版特里尔社会应激测试，对53名年龄在9至12岁、有或无产前物质接触史的受虐待寄养儿童的HPA反应模式进行了研究。曲线下面积增加值（AUC(I)）分析显示，产前物质接触或身体虐待显著增加了出现负AUC(I)（即HPA反应很少或没有反应）的可能性。在有产前物质接触和身体虐待的儿童中，85%表现出负AUC(I)。研究结果强调了应对这种综合风险的重要性。
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