Tonnarini G, Gianturco V, Cilli M, Minisola S, Cavallotti C
Department of Internal Medicine, University of Rome Sapienza, Rome, Italy.
Clin Ter. 2012;163(3):e101-6.
We hypothesize that dopaminergic receptors of dura mater may play a possible role in headache.
The dopaminergic receptors of cranial dura mater in man were studied by examining several dural zones (vascular, peri-vascular, inter-vascular) in different brain regions (basal, calvarial, tentorial, occipital, frontal, parietal, temporal).
Our results demonstrate that dopaminergic receptors are present in human cranial dura mater and that these receptors show a specific morphological location. There are more dural dopaminergic receptors in the basal region than in the calvarial one. Moreover, these receptors are more abundant in the vascular and perivascular dural zone than in the intervascular one.
The location of dopaminergic receptors in the dura mater may represent an important factor in the pathogenesis of headache. Further studies will be necessary in order to determine the role of dopaminergic system in this disease.
我们推测硬脑膜的多巴胺能受体可能在头痛中发挥作用。
通过检查不同脑区（基底、颅骨、小脑幕、枕部、额部、顶叶、颞叶）的几个硬脑膜区域（血管、血管周围、血管间），对人类颅骨硬脑膜的多巴胺能受体进行了研究。
我们的结果表明，多巴胺能受体存在于人类颅骨硬脑膜中，且这些受体具有特定的形态学定位。基底区域的硬脑膜多巴胺能受体比颅骨区域的更多。此外，这些受体在血管和血管周围硬脑膜区域比在血管间区域更丰富。
硬脑膜中多巴胺能受体的定位可能是头痛发病机制中的一个重要因素。为了确定多巴胺能系统在这种疾病中的作用，还需要进一步的研究。
