Suppr超能文献

pooled 检测有效估计曼氏血吸虫病流行率。

Pooled testing for effective estimation of the prevalence of Schistosoma mansoni.

出版信息

Am J Trop Med Hyg. 2012 Nov;87(5):850-861. doi: 10.4269/ajtmh.2012.12-0216. Epub 2012 Sep 10.

Abstract

Rapid and accurate identification of the prevalence of schistosomiasis is key for control and eradication of this devastating disease. The current screening standard for intestinal schistosomiasis is the Katz-Kato method, which look for eggs on slides of fecal matter. Although work has been done to estimate prevalence using the number of eggs on a slide, the procedure is much faster if the laboratory only reports the presence or absence of eggs on each slide. To further help reduce screening costs while maintaining accuracy, we propose a pooled method for estimating prevalence. We compare it to the standard individualed method, investigating differences in efficiency, measured by the number of slides read, and accuracy, measured by mean square error of estimation. Complication is introduced by the unknown and varying sensitivity of the procedure with population prevalence. The DeVlas model for the worm and egg distributions in the population describes how test sensitivity increases with age of the epidemic, as prevalence and intensity of infection increase, making the problem fundamentally different from earlier work in pooling. Previous literature discusses varying sensitivity with the number of positive samples within a pool, known as the "dilution effect." We model both the dilution effect and varying sensitivity with population prevalence. For model parameter values suited to younger age groups, the pooled method has less than half the mean square error of the individualed method. Thus, we can use half as many slides while maintaining accuracy. Such savings might encourage more frequent measurements in regions where schistosomiasis is a serious but neglected problem.

摘要

快速准确地确定血吸虫病的流行情况是控制和消灭这种毁灭性疾病的关键。目前肠道血吸虫病的筛查标准是加藤氏法,即在粪便涂片上寻找虫卵。虽然已经有工作试图通过涂片上的虫卵数量来估计流行率,但如果实验室只报告每张涂片上是否有虫卵,操作速度会更快。为了在保持准确性的同时进一步帮助降低筛查成本,我们提出了一种用于估计流行率的合并方法。我们将其与标准的个体方法进行比较,通过读取的幻灯片数量来衡量效率,通过估计均方误差来衡量准确性。由于人群流行率未知且检测方法的敏感性不同,会导致出现并发症。描述人群中蠕虫和虫卵分布的 DeVlas 模型说明了随着流行率和感染强度的增加,检测敏感性如何随流行年龄的增加而增加,这使得该问题与早期的合并研究有根本的不同。先前的文献讨论了在一个合并样本中阳性样本数量的变化敏感性,称为“稀释效应”。我们对合并方法进行建模,包括稀释效应和与人群流行率相关的变化敏感性。对于适合年轻年龄组的模型参数值,合并方法的均方误差小于个体方法的一半。因此,我们可以在保持准确性的同时减少一半的幻灯片数量。这种节省可能会鼓励在血吸虫病是一个严重但被忽视的问题的地区更频繁地进行测量。

相似文献

1
Pooled testing for effective estimation of the prevalence of Schistosoma mansoni.
Am J Trop Med Hyg. 2012 Nov;87(5):850-861. doi: 10.4269/ajtmh.2012.12-0216. Epub 2012 Sep 10.
2
Effective classification of the prevalence of Schistosoma mansoni.
Trop Med Int Health. 2012 Dec;17(12):1470-7. doi: 10.1111/j.1365-3156.2012.03098.x. Epub 2012 Oct 29.
5
Prevalence of schistosomiasis mansoni in indigenous Maxakali villages, Minas Gerais, Brazil.
Rev Inst Med Trop Sao Paulo. 2018;60:e26. doi: 10.1590/s1678-9946201860026. Epub 2018 Jun 28.

引用本文的文献

2
Bias Correction in Estimating Proportions by Imperfect Pooled Testing.
J Agric Biol Environ Stat. 2021;26:90-104. doi: 10.1007/s13253-020-00411-5.
4
Calculating the prevalence of soil-transmitted helminth infection through pooling of stool samples: Choosing and optimizing the pooling strategy.
PLoS Negl Trop Dis. 2019 Mar 21;13(3):e0007196. doi: 10.1371/journal.pntd.0007196. eCollection 2019 Mar.
5
Bias Correction in Estimating Proportions by Pooled Testing.
J Agric Biol Environ Stat. 2017 Dec;22(4):602-614. doi: 10.1007/s13253-017-0297-2. Epub 2017 Aug 1.
10
Effective classification of the prevalence of Schistosoma mansoni.
Trop Med Int Health. 2012 Dec;17(12):1470-7. doi: 10.1111/j.1365-3156.2012.03098.x. Epub 2012 Oct 29.

本文引用的文献

2
Effective classification of the prevalence of Schistosoma mansoni.
Trop Med Int Health. 2012 Dec;17(12):1470-7. doi: 10.1111/j.1365-3156.2012.03098.x. Epub 2012 Oct 29.
4
A comparative study of the spatial distribution of schistosomiasis in Mali in 1984-1989 and 2004-2006.
PLoS Negl Trop Dis. 2009;3(5):e431. doi: 10.1371/journal.pntd.0000431. Epub 2009 May 5.
9
Underestimation of Schistosoma mansoni prevalences.
Parasitol Today. 1992 Aug;8(8):274-7. doi: 10.1016/0169-4758(92)90144-q.
10
Epidemiology and geography of Schistosoma mansoni in Uganda: implications for planning control.
Trop Med Int Health. 2004 Mar;9(3):372-80. doi: 10.1046/j.1365-3156.2003.01176.x.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验