衰老对杓状软骨肌再生的影响。
Effects of aging on thyroarytenoid muscle regeneration.
机构信息
Department of Communicative Disorders, University of Wisconsin-Madison, Madison, Wisconsin, USA.
出版信息
Laryngoscope. 2012 Dec;122(12):2800-7. doi: 10.1002/lary.23589. Epub 2012 Sep 10.
OBJECTIVES/HYPOTHESIS: Regenerative properties of age-associated changes in the intrinsic laryngeal muscles following injury are unclear. The purpose of this study was to investigate the regenerative properties of the thyroarytenoid (TA) muscle in an aging rat model. The hypothesis was that following myotoxic injury, old animals would exhibit a decrease in mitotic activities of muscle satellite cells when compared with younger rats, suggesting reduced regenerative potential in the aging rat TA muscle.
STUDY DESIGN
Animal group comparison.
METHODS
Regeneration responses following injury to the TA muscle were examined in 18 young adult, middle-aged, and old Fischer 344/Brown Norway rats. TA muscle fiber cross-sectional area (CSA), satellite cell mitosis (number/fiber), and regeneration index (CSA injured side/CSA noninjured side) were measured and compared across age groups.
RESULTS
Young adult animals had a significantly higher regeneration index than the middle-aged and old groups. Within the lateral region of the TA muscle (LTA), the regeneration index was significantly higher in the young adult animals than in the middle-aged and old animals. The regeneration index of the medial TA was significantly higher than the LTA across all age groups.
CONCLUSIONS
The regenerative capacity of the TA muscle is impaired with increasing age.
目的/假设：损伤后内在喉肌与年龄相关的变化的再生特性尚不清楚。本研究的目的是研究衰老大鼠模型中杓状软骨肌（TA）的再生特性。假设是，与年轻大鼠相比，肌卫星细胞的有丝分裂活性在老年动物中会减少，这表明衰老大鼠 TA 肌肉的再生潜力降低。
研究设计
动物组比较。
方法
在 18 只年轻成年、中年和老年 Fischer 344/布朗-挪威大鼠中，研究了 TA 肌肉损伤后的再生反应。测量并比较了各组的 TA 肌纤维横截面积（CSA）、卫星细胞有丝分裂（数量/纤维）和再生指数（损伤侧 CSA/未损伤侧 CSA）。
结果
年轻成年动物的再生指数明显高于中年和老年组。在 TA 肌的外侧区域（LTA），年轻成年动物的再生指数明显高于中年和老年动物。在所有年龄组中，TA 的内侧再生指数均明显高于 LTA。
结论
随着年龄的增长，TA 肌肉的再生能力受损。
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