四氢异喹啉的生物催化生产。
Biocatalytic production of tetrahydroisoquinolines.
作者信息
Ruff Bettina M, Bräse S, O'Connor Sarah E
机构信息
Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
出版信息
Tetrahedron Lett. 2012 Feb 29;53(9):1071-1074. doi: 10.1016/j.tetlet.2011.12.089.
Abstract
The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.
摘要
描述了去甲乌药碱合酶的底物宽泛性。这种生物催化剂通过在皮克特-施彭格勒反应中使多巴胺与各种乙醛环化，生成了一系列多样的取代四氢异喹啉。这种酶促反应可能为一系列四氢异喹啉生物碱提供一条生物催化途径。
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