Department of Pharmacology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Expert Rev Proteomics. 2012 Aug;9(4):425-36. doi: 10.1586/epr.12.38.
Alcohol abuse can lead to a number of health and social issues. Our current inability to accurately assess long-term drinking behaviors is an important obstacle to its diagnosis and treatment. Biomarkers for chronic alcohol consumption have made a number of important advances but have yet to become highly accurate and as accepted as objective tests for other diseases. Thus, there is a crucial need for the development of more sensitive and specific markers of alcohol abuse. Recent advancements in proteomic technologies have greatly increased the potential for alcohol abuse biomarker discovery. Here, the authors review established and novel protein biomarkers for long-term alcohol consumption and the proteomic technologies that have been used in their study.
酗酒可导致诸多健康和社会问题。目前，我们无法准确评估长期饮酒行为，这是诊断和治疗的重大障碍。用于慢性酒精摄入的生物标志物已取得多项重要进展，但尚未像其他疾病的客观检测那样达到高度准确和被广泛接受的程度。因此，迫切需要开发更敏感和特异的酒精滥用标志物。近年来，蛋白质组学技术的进步极大地增加了发现酒精滥用生物标志物的潜力。本文作者综述了用于长期饮酒检测的已有和新型蛋白生物标志物，以及用于此类研究的蛋白质组学技术。
