丹参川芎嗪注射液对重度烧伤患者早期心肌损伤的影响

[Effect of salvia miltiorrhiza and Ligustrazine injection on the early myocardial damage of patients with severe burn].

作者信息

Ding Ling-tao, Zhu Yu-gang, Gu Zai-qiu, Cai Liang-liang, Peng Jing-liang, Lü Guo-zhong

机构信息

Department of Burns and Plastic Surgery, the Third Affiliated Hospital of Nantong University, Wuxi 214041, China.

出版信息

Zhonghua Shao Shang Za Zhi. 2012 Jun;28(3):170-2.

PMID:22967970

Abstract

OBJECTIVE

To observe the effect of salvia miltiorrhiza and ligustrazine injection on the early myocardial damage of severely burned patients.

METHODS

Twenty severely burned patients hospitalized from January 2010 to August 2011, with burn area equal to or more than 50% TBSA, were divided into two groups following hospitalization sequence, with odd number patients entering treatment group (T, n = 10) and even number patients entering control group (C, n = 10). Patients in C group were treated with routine methods, including fluid resuscitation based on the Third Military Medical University formula, anti-infection treatment, support treatment, and organ-protection treatment, etc. In addition to routine treatment methods, patients in T group received intravenous infusion of 250 mL glucose injection (50 g/L) containing 10 mL salvia miltiorrhiza and ligustrazine concoction, once a day, and continued for three days. Venous blood of patients was drawn at post burn hour (PBH) 12, 24, 48, and 72 to determine the plasma levels of cardiac troponin I (cTnI), creatine kinase isozyme MB (CK-MB), and atrial natriuretic peptide (ANP). Data were processed with t test.

RESULTS

At each time point, levels of cTnI, CK-MB, and ANP were lower in T group than in C group. Differences in contents of these parameters between two groups were statistically significant at most time points, with t values from 2.136 to 2.918, P < 0.05 or P < 0.01. Plasma levels of cTnI, CK-MB, and ANP in both groups peaked at PBH 12, which were respectively (28 ± 10) ng/mL, (76 ± 13) U/L, (430 ± 87) pg/mL in T group, and (38 ± 11) ng/mL, (87 ± 10) U/L, (453 ± 91) pg/mL in C group. From PBH 24 to 72, contents of above-mentioned parameters decreased gradually in both groups.

CONCLUSIONS

Early use of salvia miltiorrhiza and ligustrazine injection in severely burned patients can effectively reduce myocardial damage, thus protect the myocardium from injury.

摘要

目的

观察丹参川芎嗪注射液对重度烧伤患者早期心肌损伤的影响。

方法

选取2010年1月至2011年8月住院的重度烧伤患者20例，烧伤面积≥50%TBSA，按住院顺序分为两组，奇数患者进入治疗组（T组，n = 10），偶数患者进入对照组（C组，n = 10）。C组采用常规治疗方法，包括按第三军医大学公式进行液体复苏、抗感染治疗、支持治疗及器官保护治疗等。T组除常规治疗方法外，每日静脉输注含10 mL丹参川芎嗪合剂的250 mL葡萄糖注射液（50 g/L），连续3天。于烧伤后12、24、48及72小时抽取患者静脉血，测定血浆心肌肌钙蛋白I（cTnI）、肌酸激酶同工酶MB（CK-MB）及心钠素（ANP）水平。数据采用t检验处理。

结果

各时间点T组cTnI、CK-MB及ANP水平均低于C组。两组这些参数含量在多数时间点差异有统计学意义，t值为2.136至2.918，P < 0.05或P < 0.01。两组血浆cTnI、CK-MB及ANP水平均在烧伤后12小时达峰值，T组分别为（28±10）ng/mL、（76±13）U/L、（430±87）pg/mL，C组分别为（38±11）ng/mL（87±10）U/L、（453±91）pg/mL。从烧伤后24小时至72小时，两组上述参数含量均逐渐下降。