Olshan A F, Teschke K, Baird P A
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Am J Epidemiol. 1990 Feb;131(2):312-21. doi: 10.1093/oxfordjournals.aje.a115500.
The authors conducted an exploratory case-control study of paternal employment as a fire fighter and the risk of birth defects among offspring. By means of a population-based registry in British Columbia, 22,192 liveborn children with birth defects were identified for the period, 1952-1973. Two comparisons were made to evaluate the risk among offspring of firemen: 1) comparison with the risk among offspring of fathers employed in other occupations using a matched (two per case) control group, and 2) comparison with the risk among offspring of policemen. Among the 20 birth defect groups studied, an association was found for paternal employment as a fire fighter (relative to all other occupations) and increased risks were observed for ventricular septal defects (odds ratio (OR) = 2.70, 95% confidence interval (Cl) 1.02-7.18) and atrial septal defects (OR = 5.91, 95% Cl 1.60-21.83) among offspring. When compared with policemen, firemen had increased risks of having a child with a ventricular septal defect (OR = 4.68, 95% Cl 1.66-13.17) and atrial septal defect (OR = 3.76, 95% Cl 1.40-10.07). Analyses using a pathogenetic classification for these heart defects yielded similar increased odds ratios for firemen.
作者开展了一项探索性病例对照研究，探究父亲作为消防员的职业与子代出生缺陷风险之间的关系。通过不列颠哥伦比亚省的一个基于人群的登记系统，在1952年至1973年期间确定了22192名患有出生缺陷的活产儿童。为评估消防员子代的风险，进行了两项比较：1）使用匹配（每例两个）对照组，与从事其他职业的父亲的子代风险进行比较；2）与警察的子代风险进行比较。在所研究的20个出生缺陷组中，发现父亲作为消防员的职业（相对于所有其他职业）与子代风险存在关联，且观察到子代患室间隔缺损（优势比（OR）=2.70，95%置信区间（Cl）1.02 - 7.18）和房间隔缺损（OR = 5.91，95% Cl 1.60 - 21.83）的风险增加。与警察相比，消防员生育患有室间隔缺损（OR = 4.68，95% Cl 1.66 - 13.17）和房间隔缺损（OR = 3.76，95% Cl 1.40 - 10.07）孩子的风险增加。对这些心脏缺陷使用病因分类进行分析，得出消防员的优势比也有类似增加。
