Javadi Abbas Ali, Ataei Behrooz, Khorvash Farzin, Babak Anahita, Rostami Mojtaba, Mostafavizadeh Kamyar, Naeini Alireza Emami, Meidani Mohsen, Salehi Hasan, Avijgan Majid, Sherkat Roya, Yazdani Mohammad Reza, Rezaei Farshid
Associate Professor, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2011 Dec;16(12):1550-4.
During August 2009, novel H1N1 influenza virus began causing illness in Isfahan. Since rates of hospitalization and mortality due to the disease have varied widely in different countries, we described the clinical, radiologic, and demographic features of H1N1 hospitalized patients in a hospital in Isfahan.
This cross-sectional study was conducted in Alzahra Hospital during September 2009 to February 2010. Totally, 216 patients with confirmed, probable, or suspected cases of 2009 influenza A (H1N1) were admitted.
Most patients were women (50.5%). Mean age of patients was 26.6 ± 19.5 years. The most common complains on admission were respiratory symptoms (91.6%, n= 198), fever (88.4%, n = 191), myalgia (65.7%, n = 142). In addition, 120 patients (56%) had at least one underlying medical disorder. Thirty-six patients (16.7%) died. Mortality was higher in children under 5 years old (10/36, 10%) and female cases (63.9% of died patients). Predicting variables affecting mortality were intensive care unit (ICU) admission and procalcitonin (PCT) > 0.5. Antiviral treatment was prescribed for 200 (92.5%) of the 216 patients.
Based on the findings of the present study, novel H1N1 influenza is highly prevalent among the youth. Moreover, it causes a relatively high morbidity rate. Therefore, people need to be encouraged to have vaccination against 2009 H1N1. Early diagnosis and treatment is related to less admission and shorter duration of hospitalization.
2009年8月期间，新型H1N1流感病毒开始在伊斯法罕引发疾病。由于该疾病在不同国家的住院率和死亡率差异很大，我们描述了伊斯法罕一家医院中H1N1住院患者的临床、放射学和人口统计学特征。
这项横断面研究于2009年9月至2010年2月在阿尔扎赫拉医院进行。共有216例确诊、可能或疑似2009甲型流感（H1N1）病例的患者入院。
大多数患者为女性（50.5%）。患者的平均年龄为26.6±19.5岁。入院时最常见的主诉是呼吸道症状（91.6%，n = 198）、发热（88.4%，n = 191）、肌痛（65.7%，n = 142）。此外，120例患者（56%）至少有一种基础疾病。36例患者（16.7%）死亡。5岁以下儿童（10/36，10%）和女性病例（死亡患者的63.9%）的死亡率较高。影响死亡率的预测变量是入住重症监护病房（ICU）和降钙素原（PCT）>0.5。216例患者中有200例（92.5%）接受了抗病毒治疗。
根据本研究的结果，新型H1N1流感在年轻人中高度流行。此外，它导致相对较高的发病率。因此，需要鼓励人们接种2009 H1N1疫苗。早期诊断和治疗与较少的入院率和较短的住院时间相关。
