Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, MN 55905, USA.
Hum Pathol. 2012 Nov;43(11):2084-7. doi: 10.1016/j.humpath.2012.05.017. Epub 2012 Sep 10.
In this report, we describe the first case of a patient with an IgG4-related paratesticular pseudotumor. He had histologically proven autoimmune pancreatitis, then later developed a scrotal mass. The orchiectomy specimen revealed that this was a paratesticular pseudotumor with histopathologic and immunohistochemistry findings characteristic of IgG4-related disease. Paratesticular pseudotumors are uncommon causes of intrascrotal masses and have an unexplained pathogenesis. A variety of genitourinary manifestations of IgG4-related disease including IgG4-related tubulointerstitial nephritis, IgG4-related ureteral pseudotumors, and IgG4-related prostatitis has been previously reported. The current case highlights the need to have a high index of suspicion for IgG4-tissue infiltration in patients with known autoimmune pancreatitis, particularly those with a pseudotumor.
在本报告中，我们描述了首例 IgG4 相关的睾丸旁假性肿瘤患者。他患有组织学证实的自身免疫性胰腺炎，随后出现阴囊肿块。睾丸切除术标本显示，这是一个睾丸旁假性肿瘤，具有组织病理学和免疫组化特征，符合 IgG4 相关疾病。睾丸旁假性肿瘤是阴囊内肿块的不常见原因，其发病机制尚不清楚。以前曾报道过 IgG4 相关疾病的多种泌尿生殖系统表现，包括 IgG4 相关肾小管间质性肾炎、IgG4 相关输尿管假性肿瘤和 IgG4 相关前列腺炎。本病例强调了在已知自身免疫性胰腺炎患者中，特别是在假性肿瘤患者中，对 IgG4 组织浸润有高度怀疑的必要性。
