Langer R M, Cohen B, Rahmel A
Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.
Transplant Proc. 2012 Sep;44(7):2130-1. doi: 10.1016/j.transproceed.2012.07.125.
In 1967, the Dutch immunologist Jon van Rood called Eurotransplant into life. From the beginning it was a non-profit private foundation. Initially it was a loose cooperation, where tissue typing laboratories and transplantation centers joined to achieve a better result for their kidney patients, a longer survival based on better immunological matching from a bigger donor pool. Other centers from the Benelux states, Germany and Austria soon joined the first few cooperating centers. Switzerland was also a member of Eurotransplant, but left the organization in 1978. Based on the pioneering work of the Leiden histocompatibility lab, the allocation system became more and more sophisticated and was extended to other solid organs. Since the 1980s Eurotransplant has allocated donor livers, hearts, and pancreas. Thereafter, the allocation also included lungs and small bowel. From 1996 a new kidney allocation system, the ETKAS, was introduced, and after the Acceptable Mismatch program and the Eurotransplant Senior Program (known unofficially as "old-for-old" program) were introduced. The main principle remains to adapt the allocation rules continuously according to the newest scientific data serving all organs. In 1991 the German reunification centers in the former Eastern Germany became part of Eurotransplant. In 1999, Slovenia, and in 2007 Croatia joined Eurotransplant. For the transplant centers in these two countries, membership meant positive changes and is regarded as a success story. Both donor numbers and transplant possibilities increased and equal chances are assured for their patients on the common Eurotransplant waiting list. Hungary, joining Eurotransplant next year, hopes to experience the same.
1967年,荷兰免疫学家琼·范·罗德创立了欧洲移植组织。从一开始,它就是一个非营利性的私人基金会。最初,它是一种松散的合作形式,组织配型实验室和移植中心联合起来,为肾病患者取得更好的治疗效果,即通过从更大的供体库中进行更好的免疫匹配,延长患者的生存期。比荷卢经济联盟国家、德国和奥地利的其他中心很快加入了最初的几个合作中心。瑞士也曾是欧洲移植组织的成员,但于1978年退出了该组织。基于莱顿组织相容性实验室的开创性工作,分配系统变得越来越复杂,并扩展到了其他实体器官。自20世纪80年代以来,欧洲移植组织开始分配供体肝脏、心脏和胰腺。此后,分配范围还包括肺和小肠。1996年引入了一种新的肾脏分配系统——欧洲移植肾脏分配系统(ETKAS),之后又引入了可接受错配计划和欧洲移植老年计划(非官方称为“老对老”计划)。主要原则仍然是根据最新的科学数据不断调整分配规则,以适用于所有器官。1991年,前东德的德国统一中心成为欧洲移植组织的一部分。1999年,斯洛文尼亚加入,2007年克罗地亚加入欧洲移植组织。对于这两个国家的移植中心来说,加入意味着积极的变化,被视为一个成功的案例。供体数量和移植可能性都增加了,并且在共同的欧洲移植等待名单上,为它们的患者确保了平等的机会。匈牙利明年将加入欧洲移植组织,希望也能有同样的经历。