College of Science, Ibaraki University, Bunkyo, Mito 310-8512, Japan.
Chem Biodivers. 2012 Sep;9(9):1635-58. doi: 10.1002/cbdv.201100446.
The complexes of group-10 metals, Ni, Pd, and Pt, with biological molecules and related ligands have been attracting increasing attention in recent years due to their reactivities and functions, such as catalysts and drugs, and their biological relevance. The well-defined structures and kinetic inertness especially of Pt complexes have been used as the sites for weak interactions with other molecules. The Ni complexes have been reported as models not only for Ni enzymes but also for other metalloenzyme active sites for deeper understanding of the reactivities such as oxygen activations and detailed electronic structures. Pd Complexes are widely known for their catalytic activities in conversions of various organic molecules including useful biological molecules, such as Suzuki-Miyaura cross-coupling, while Pt complexes have been intensively studied for their antitumor activities. We focus in this review on our recent results on weak interactions and reactivities of the group-10 metal complexes with biological molecules and related compounds, and discuss their structural features and some new properties pointing to functional possibilities.
近年来，由于其反应性和功能（如催化剂和药物）以及与生物的相关性，第 10 族金属（Ni、Pd 和 Pt）与生物分子和相关配体的配合物引起了越来越多的关注。Pt 配合物具有明确的结构和动力学惰性，可作为与其他分子发生弱相互作用的位点。Ni 配合物不仅被报道为 Ni 酶的模型，也被报道为其他金属酶活性位点的模型，以更深入地了解其反应性，如氧活化和详细的电子结构。Pd 配合物因其在各种有机分子（包括有用的生物分子）转化中的催化活性而广为人知，例如 Suzuki-Miyaura 交叉偶联，而 Pt 配合物则因其抗肿瘤活性而受到深入研究。我们在这篇综述中重点关注我们最近在第 10 族金属配合物与生物分子和相关化合物的弱相互作用和反应性方面的研究结果，并讨论其结构特征和一些指向功能可能性的新性质。
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