Bezalel Shira, Asher Ilan, Elbirt Daniel, Sthoeger Zev Moshe
Department of Medicine B, Kaplan Medical Center, Rehovot, affiliated with Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Isr Med Assoc J. 2012 Aug;14(8):508-14.
Current treatments for systemic lupus erythematosus (SLE) are effective in reducing morbidity and mortality but are not specific and have severe adverse effects. Based on understanding of the different dysregulated immunological pathways involved in SLE pathogenesis, specific targeted therapies were developed. This review presents the current and the near-future novel biological immune targeted treatments, such as B cell-targeted therapy, cytokine blockade, peptide-based treatments and other novel treatments for SLE.
目前系统性红斑狼疮（SLE）的治疗方法在降低发病率和死亡率方面是有效的，但缺乏特异性且有严重的不良反应。基于对SLE发病机制中不同失调免疫途径的理解，开发了特异性靶向治疗方法。本文综述了当前以及不久将来新型生物免疫靶向治疗方法，如针对SLE的B细胞靶向治疗、细胞因子阻断、基于肽的治疗及其他新型治疗方法。
