三氮唑连接的亚氨基苯酚杯[4]芳烃共轭物的 Mn2+、Fe2+、Co2+、Ni2+、Cu2+ 和 Zn2+ 配合物的多传感器阵列，用于选择性识别 Asp、Glu、Cys 和 His。
Multiple sensor array of Mn2+, Fe2+, Co2+, Ni2+, Cu2+, and Zn2+ complexes of a triazole linked imino-phenol based calix[4]arene conjugate for the selective recognition of Asp, Glu, Cys, and His.
机构信息
Bioinorganic Laboratory, Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.
出版信息
Anal Chem. 2012 Oct 2;84(19):8294-300. doi: 10.1021/ac301821c. Epub 2012 Sep 14.
The triazole linked o-imino phenol appended calix[4]arene conjugate (L) has been synthesized and characterized. The structure of L has been established based on single crystal XRD. The binding and recognition behavior of conjugate, L toward the transition metal ions, such as Mn(2+), Fe(2+), Co(2+), Ni(2+), Cu(2+), and Zn(2+), has been demonstrated using fluorescence, absorption and ESI-MS techniques. The in situ prepared complexes of these metal ions, namely, [Mn(2)L], [Fe(2)L], [Co(2)L], [Ni(2)L], [Cu(2)L], and [Zn(2)L] have shown recognition toward Glu, Asp, His and Cys. Hence L provides a multiple sensing molecular tool where the response for the recognition of biologically active amino acids of metalloproteins is elicited by the presence of specific metal ion.
已合成并表征了三唑键合邻亚氨基苯酚修饰杯[4]芳烃缀合物（L）。根据单晶 XRD 确定了 L 的结构。使用荧光、吸收和 ESI-MS 技术研究了该缀合物 L 与过渡金属离子（如 Mn(2+)、Fe(2+)、Co(2+)、Ni(2+)、Cu(2+)和 Zn(2+)）的结合和识别行为。通过原位制备这些金属离子的配合物，即 [Mn(2)L]、[Fe(2)L]、[Co(2)L]、[Ni(2)L]、[Cu(2)L] 和 [Zn(2)L]，对 Glu、Asp、His 和 Cys 表现出识别作用。因此，L 提供了一种多传感分子工具，其中通过存在特定金属离子来引发对金属蛋白酶中生物活性氨基酸的识别响应。
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