Computational Systems Biology Group, Numerical Analysis and Modeling, Zuse Institute Berlin, Takustr. 7, 14195 Berlin, Germany.
Theriogenology. 2012 Oct 15;78(7):1415-28. doi: 10.1016/j.theriogenology.2012.04.017.
Our model of the bovine estrous cycle is a set of ordinary differential equations which generates hormone profiles of successive estrous cycles with several follicular waves per cycle. It describes the growth and decay of the follicles and the corpus luteum, as well as the change of the key reproductive hormones, enzymes and processes over time. In this work we describe recent developments of this model towards the administration of prostaglandin F2α. We validate our model by showing that the simulations agree with observations from synchronization studies and with measured progesterone data after single dose administrations of synthetic prostaglandin F2α.
我们的牛发情周期模型是一组常微分方程，它可以生成具有多个卵泡波的连续发情周期的激素谱。它描述了卵泡和黄体的生长和衰退，以及关键生殖激素、酶和过程随时间的变化。在这项工作中，我们描述了该模型在施用前列腺素 F2α 方面的最新进展。我们通过展示模拟结果与同步研究的观察结果以及单次给予合成前列腺素 F2α 后的测量孕酮数据一致，验证了我们的模型。
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