Taheri M, Hashemi M, Eskandari-Nasab E, Fazaeli A, Arababi F, Bahrani-Zeidabadi M, Bahari G
Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Prague Med Rep. 2012;113(3):217-22. doi: 10.14712/23362936.2015.19.
It is known that interleukin-18 (IL-18) is a proinflammatory cytokine with dual effects on tumor development and progression. It can increase the immune defense against tumor cells. Polymorphisms in the IL-18 genes are known to influence both expression levels and may be associated with outcome of cancers. This study was aimed to find out the possible association of IL-18 polymorphism at position -607 C/A (rs1946518) with breast cancer in a sample of Iranian population. We investigated IL-18 rs1946518 polymorphism on 72 breast cancer patients and 93 cancer free women. Genotyping was done using amplification refractory mutation system-PCR (ARMS-PCR). We found no significant differences between breast cancer patients and control subjects regarding IL-18 rs1946518 polymorphism (χ2=1.78, p=0.411). In conclusion, our finding showed that IL-18 rs1946518 polymorphism was not associated with breast cancer in a sample of Iranian population.
已知白细胞介素-18（IL-18）是一种对肿瘤发生和发展具有双重作用的促炎细胞因子。它可以增强针对肿瘤细胞的免疫防御。已知IL-18基因的多态性会影响表达水平，并且可能与癌症的预后相关。本研究旨在在伊朗人群样本中找出IL-18基因-607 C/A位点（rs1946518）的多态性与乳腺癌之间的可能关联。我们对72例乳腺癌患者和93例无癌女性进行了IL-18 rs1946518多态性调查。采用扩增阻滞突变系统-聚合酶链反应（ARMS-PCR）进行基因分型。我们发现，在IL-18 rs1946518多态性方面，乳腺癌患者与对照受试者之间无显著差异（χ2=1.78，p=0.411）。总之，我们的研究结果表明，在伊朗人群样本中，IL-18 rs1946518多态性与乳腺癌无关。
