从金丝桃属植物中分离得到的香叶木素二聚体衍生物。

Prenylated phloroglucinol derivatives from Hypericum sampsonii.

机构信息

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.

出版信息

Fitoterapia. 2012 Dec;83(8):1540-7. doi: 10.1016/j.fitote.2012.08.022. Epub 2012 Sep 6.

DOI:10.1016/j.fitote.2012.08.022

PMID:22981504

Abstract

Six new acylphloroglucinol derivatives, sampsonols A-F (1-6), were isolated from the petroleum ether extract of the aerial parts of Hypericum sampsonii. The structures and relative configurations of sampsonols A-F were elucidated by extensive spectroscopic analyses. All these compounds were tested for their in vitro cytotoxic and anti-inflammatory activities. Sampsonols A and B (1 and 2) showed significant cytotoxicity against four human tumor cell lines with IC(50) values in the range of 13-28μM, whereas sampsonols C and F (3 and 6) showed potent inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with IC(50) values of 27.3 and 29.3μM, respectively.

摘要

从 Hypericum sampsonii 的地上部分的石油醚提取物中分离得到了六个新的酰基间苯三酚衍生物，即山酮醇 A-F（1-6）。通过广泛的光谱分析阐明了山酮醇 A-F 的结构和相对构型。所有这些化合物都进行了体外细胞毒性和抗炎活性测试。山酮醇 A 和 B（1 和 2）对四种人肿瘤细胞系表现出显著的细胞毒性，IC50 值在 13-28μM 范围内，而山酮醇 C 和 F（3 和 6）对 LPS 诱导的 RAW 264.7 巨噬细胞中 NO 产生具有很强的抑制活性，IC50 值分别为 27.3 和 29.3μM。