T 细胞抗原受体介导的信号转导在初始和效应/记忆 T 细胞中。
Signal transduction via the T cell antigen receptor in naïve and effector/memory T cells.
机构信息
The Department of Microbiology & Immunology, Cornell University, Ithaca, NY, USA.
出版信息
Int J Biochem Cell Biol. 2012 Dec;44(12):2129-34. doi: 10.1016/j.biocel.2012.08.023. Epub 2012 Sep 4.
Abstract
T cells play an indispensable role in immune defense against infectious agents, but can also be pathogenic. These T cells develop in the thymus, are exported into the periphery as naïve cells and participate in immune responses. Upon recognition of antigen, they are activated and differentiate into effector and memory T cells. While effector T cells carry out the function of the immune response, memory T cells can last up to the life time of the individual, and are activated by subsequent antigenic exposure. Throughout this life cycle, the T cell uses the same receptor for antigen, the T cell Receptor, a complex multi-subunit receptor. Recognition of antigen presented by peptide/MHC complexes on antigen presenting cells unleashes signaling pathways that control T cell activation at each stage. In this review, we discuss the signals regulated by the T cell receptor in naïve and effector/memory T cells.
摘要
T 细胞在抵御感染因子的免疫防御中发挥不可或缺的作用，但也可能具有致病性。这些 T 细胞在胸腺中发育，作为幼稚细胞输出到外周，并参与免疫反应。在识别抗原后，它们被激活并分化为效应 T 细胞和记忆 T 细胞。虽然效应 T 细胞执行免疫反应的功能，但记忆 T 细胞可以持续到个体的寿命，并且可以通过随后的抗原暴露而被激活。在整个生命周期中，T 细胞使用相同的抗原受体，即 T 细胞受体，这是一种复杂的多亚单位受体。识别抗原呈递细胞上的肽/MHC 复合物所呈递的抗原会引发信号通路，从而控制 T 细胞在每个阶段的激活。在这篇综述中，我们讨论了 T 细胞受体在幼稚 T 细胞和效应/T 记忆细胞中调节的信号。
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