衰老生物标志物与针对老年人的放射治疗：该领域的未来。

Biomarkers of aging and radiation therapy tailored to the elderly: future of the field.

机构信息

Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

出版信息

Semin Radiat Oncol. 2012 Oct;22(4):334-8. doi: 10.1016/j.semradonc.2012.05.010.

DOI:10.1016/j.semradonc.2012.05.010

PMID:22985816

Abstract

An increasing proportion of cancer care will be delivered to elderly patients. There is a wide range of health status among the elderly, and "chronological age" may differ substantially from "biological age." Biomarkers of aging may be used to better determine a patient's biological age and would have potential clinical implications for the treatment of elderly patients with cancer. In this article, the authors review the current status of biomarkers related to aging and how these biomarkers may relate to treatment decisions for elderly patients with cancer. They also discuss potential implementation strategies for such biomarkers into future clinical trials.

摘要

越来越多的癌症护理将提供给老年患者。老年人的健康状况差异很大，“年龄”与“生物年龄”可能有很大不同。衰老的生物标志物可用于更好地确定患者的生物年龄，并可能对治疗老年癌症患者具有潜在的临床意义。本文作者综述了与衰老相关的生物标志物的现状，以及这些生物标志物如何与老年癌症患者的治疗决策相关，并讨论了将这些生物标志物纳入未来临床试验的潜在实施策略。