Department of Cardiology, Denizli State Hospital, Denizli, Turkey.
J Atheroscler Thromb. 2013;20(2):134-41. doi: 10.5551/jat.13920. Epub 2012 Sep 18.
Inflammation is a critical participant in mediating all stages of cardiovascular disease. Studies related with chitotriosidase that was recently found to be relevant to arterial inflammation. In this study we evaluated activity of serum chitotriosidase in acute coronary syndrome patients and its relationship with cardiovascular events, cardiac enzymes and inflammatory indicators.
We prospectively analyzed consecutive 30 patients with ST-segment elevation myocardial infarction, 30 patients with non ST-segment elevation myocardial infarction, 30 patients with unstable angina pectroris who were admitted to our intensive care unit and 30 healthy people (average age 56.86±10.44 years, 81 male) between Jaunary and June 2010. Details of baseline clinical characteristics, biochemical values, receiving treatment and basal ECG findings were recorded. Data of patients with coronary angiography were evaluated.
Cut off value of chitotriosidase was calculated 82.00 mmol·ml-1·h-1, with 83 percent sensitivity and 72 percent spesificity. The activity of chitotriosidase in acute coronary syndrome group was 88.85±23.08 mmol·ml-1 ·h-1, where as the control group was 68.47±28.44 mmol·ml-1·h-1, respectively p=0.001).The highest activity of chitotriosidase (96.11±19.77 mmol·ml-1·h-1) was found in ST-segment elevation myocardial infarction group and the minimal activity of chitotriosidase was in the control group (68.47±28.44 mmol·ml-1·h-1) (p= 0.001). The activity of chitotriosidase in ST-segment elevation myocardial infarction and non ST-segment elevation myocardial infarction groups were significantly higher than control group (p=0.001 and p=0.045). When acute coronary syndrome groups compared to control; a positive correlation was found between chitotriosidase activity and hs-CRP (r=0.21, p= 0.046), troponin T (r=0.25, p=0.016), creatine kinase-MB (r=0.20, p=0.059).
The activity of chitotriosidase is increased in acute coronary syndrome patients. Chitotriosidase is higher in ST-segment elevation myocardial infaction group than non ST-segment elevation myocardial infarction and unstable angina pectoris group.
炎症是介导心血管疾病各个阶段的关键参与者。最近发现几丁质酶与动脉炎症有关的研究与之相关。在这项研究中，我们评估了急性冠状动脉综合征患者血清几丁质酶的活性及其与心血管事件、心肌酶和炎症指标的关系。
我们前瞻性分析了 2010 年 1 月至 6 月期间连续入住我院重症监护病房的 30 例 ST 段抬高型心肌梗死患者、30 例非 ST 段抬高型心肌梗死患者、30 例不稳定型心绞痛患者和 30 名健康人（平均年龄 56.86±10.44 岁，81 名男性）。记录了基线临床特征、生化值、治疗情况和基础心电图检查结果等详细信息。评估了接受冠状动脉造影的患者的数据。
计算出几丁质酶的截断值为 82.00mmol·ml-1·h-1，具有 83%的敏感性和 72%的特异性。急性冠状动脉综合征组的几丁质酶活性为 88.85±23.08mmol·ml-1·h-1，而对照组为 68.47±28.44mmol·ml-1·h-1，p=0.001）。几丁质酶活性最高（96.11±19.77mmol·ml-1·h-1）见于 ST 段抬高型心肌梗死组，最低见于对照组（68.47±28.44mmol·ml-1·h-1）（p=0.001）。ST 段抬高型心肌梗死组和非 ST 段抬高型心肌梗死组的几丁质酶活性明显高于对照组（p=0.001 和 p=0.045）。当急性冠状动脉综合征组与对照组相比时，几丁质酶活性与 hs-CRP（r=0.21，p=0.046）、肌钙蛋白 T（r=0.25，p=0.016）和肌酸激酶同工酶-MB（r=0.20，p=0.059）呈正相关。
急性冠状动脉综合征患者的几丁质酶活性增加。ST 段抬高型心肌梗死组的几丁质酶高于非 ST 段抬高型心肌梗死组和不稳定型心绞痛组。
