心脏疾病中纤维母细胞的起源和致心律失常潜能。
The origin and arrhythmogenic potential of fibroblasts in cardiac disease.
机构信息
Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, 522 First Avenue, Smilow Building 8th Floor, New York, NY 10016, USA.
出版信息
J Cardiovasc Transl Res. 2012 Dec;5(6):760-7. doi: 10.1007/s12265-012-9408-1. Epub 2012 Sep 18.
Abstract
Fibroblasts play a major role in normal cardiac physiology and in the response of the heart to injury and disease. Cardiac electrophysiological research has primarily focused on the mechanisms of remodeling that accompany cardiac disease with an emphasis on myocyte electrophysiology. Recently, there has been increasing interest in the potential role of fibroblasts in cardiac electrophysiology. This review focuses on the arrhythmia mechanisms involving interactions between myocytes and fibroblasts. We also discuss the available evidence supporting the contribution of intracardiac and extracardiac sources to the fibroblast and myofibroblast populations in diseased hearts.
摘要
成纤维细胞在正常心脏生理学和心脏对损伤和疾病的反应中起着重要作用。心脏电生理学研究主要集中在伴随心脏病的重构机制上，重点是心肌细胞电生理学。最近，人们对成纤维细胞在心脏电生理学中的潜在作用越来越感兴趣。这篇综述的重点是涉及心肌细胞和成纤维细胞相互作用的心律失常机制。我们还讨论了支持心脏疾病中心内和心外来源对成纤维细胞和肌成纤维细胞群体的贡献的现有证据。
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Myofibroblasts and smooth muscle cells in human myocardial scars: Possible origins and inductive factors.人类心肌瘢痕中的肌成纤维细胞和平滑肌细胞：可能的起源和诱导因素。
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