Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany.
Ann Oncol. 2012 Sep;23 Suppl 10:x28-32. doi: 10.1093/annonc/mds363.
Gliomas are more or less diffuse tumours with the ability to infiltrate surrounding functional brain tissue. Thus, curative surgical treatment generally cannot be achieved. Despite these limitations, open tumour resection represents one of the mainstays in glioma treatment settings. Beyond tissue sampling for accurate histological and molecular genetic evaluation, decompressive effects in the case of space occupying tumours and oncologically relevant cytoreductive effects of microsurgery have been reported in selected patients with glioma of different grades. This paper provides practical considerations in order to integrate the concept of a personalized surgical therapy into the prognostic network of low- and high-grade gliomas, covering both microsurgery and stereotactic biopsy techniques.
神经胶质瘤是或多或少弥漫性的肿瘤，具有浸润周围功能性脑组织的能力。因此，通常无法进行治愈性的手术治疗。尽管存在这些局限性，但开放性肿瘤切除术仍然是神经胶质瘤治疗方案的主要方法之一。除了为准确的组织学和分子遗传学评估进行组织取样外，在某些分级不同的神经胶质瘤患者中，占位性肿瘤的减压作用和显微镜手术的肿瘤相关细胞减少作用也有报道。本文提供了一些实用的考虑因素，以便将个性化手术治疗的理念整合到低级别和高级别神经胶质瘤的预后网络中，涵盖了显微镜手术和立体定向活检技术。
