Mirkazemi Corinne, Bereznicki Luke R, Peterson Gregory M
School of Pharmacy, University of Tasmania, Hobart, Tasmania, Australia.
ANZ J Surg. 2012 Dec;82(12):913-7. doi: 10.1111/j.1445-2197.2012.06203.x. Epub 2012 Sep 19.
To identify enablers and barriers to thromboprophylaxis prescribing following hip and knee arthroplasty, from the perspective of orthopaedic surgeons.
An invitation to participate in an online survey was distributed electronically to Arthroplasty Society of Australia members (n = 103). The survey collected demographic details, thromboprophylaxis attitudes and clinical practice of the orthopaedic surgeons, and explored their familiarity with contemporary national and international guidelines.
Twenty-five surgeons (24%) completed the survey, all male with a median of 20 years of practice as orthopaedic surgeons (range: 8-27 years). Most surgeons (92%) practised predominantly in the private sector, and conducted both hip and knee arthroplasties each month. While all surgeons prescribed chemoprophylaxis following arthroplasty, most surgeons (64%) were uncertain to what extent it would prevent fatal pulmonary embolism (PE). The pharmacological agents of choice were low molecular weight heparin (48%) and aspirin (44%). One-third of surgeons were not familiar with the National Health and Medical Research Council recommendations for thromboprophylaxis in hip and knee arthroplasty patients. After reviewing a summary of the recommendations, most surgeons (80%) indicated they were inappropriate, commonly citing that they were grounded on an insufficient evidence base and should include aspirin as a sole chemoprophylaxis option.
There are clearly strong barriers to the translation of current thromboprophylaxis guidelines into practice. Many surgeons doubt the effectiveness of chemoprophylaxis to prevent fatal PE, perceive the risk of venous thromboembolism following surgery to be low, are unfamiliar with current national guidelines or believe the guidelines are grounded on inappropriate evidence.
从骨科医生的角度,确定髋膝关节置换术后血栓预防用药的促进因素和障碍。
通过电子邮件向澳大利亚关节置换协会成员(n = 103)发放参与在线调查的邀请。该调查收集了骨科医生的人口统计学细节、血栓预防态度和临床实践情况,并探讨了他们对当代国家和国际指南的熟悉程度。
25名外科医生(24%)完成了调查,均为男性,作为骨科医生的中位从业年限为20年(范围:8 - 27年)。大多数外科医生(92%)主要在私立部门执业,每月都进行髋膝关节置换手术。虽然所有外科医生在关节置换术后都开具化学预防药物,但大多数外科医生(64%)不确定其在预防致命性肺栓塞(PE)方面的效果如何。首选的药物是低分子量肝素(48%)和阿司匹林(44%)。三分之一的外科医生不熟悉国家卫生与医学研究委员会关于髋膝关节置换术患者血栓预防的建议。在查看了建议摘要后,大多数外科医生(80%)表示这些建议不合适,常见的理由是其证据基础不足,且应将阿司匹林作为唯一的化学预防选择。
将当前的血栓预防指南转化为实际操作显然存在很大障碍。许多外科医生怀疑化学预防预防致命性PE的有效性,认为术后静脉血栓栓塞的风险较低,不熟悉当前的国家指南,或者认为这些指南的证据基础不合适。