脑室注射食欲素 2 受体拮抗剂可促进 REM 睡眠。
Intracerebroventricular injection of orexin-2 receptor antagonist promotes REM sleep.
机构信息
Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
出版信息
Behav Brain Res. 2013 Jan 15;237:59-62. doi: 10.1016/j.bbr.2012.09.015. Epub 2012 Sep 16.
Orexins are important regulators of sleep-wakefulness (S-W). Rats were intracerebroventricularly (ICV) administered selective orexin-2 receptor antagonist, TCS-OX2-29. There was decreased wakefulness due to a decrease in the average wake episode duration and an increased REM sleep due to an increase in the number of REM episodes, indicating an inhibitory role of the central orexin-2 receptors on REM sleep generation.
食欲素是睡眠觉醒（S-W）的重要调节因子。研究人员向大鼠侧脑室（ICV）内给予选择性食欲素-2 受体拮抗剂 TCS-OX2-29，发现大鼠觉醒减少是由于平均觉醒持续时间缩短，快速眼动（REM）睡眠增加是由于 REM 睡眠期数增加，这表明中枢食欲素-2 受体对 REM 睡眠的产生具有抑制作用。
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