Fernandes Maurício, Munhoz Renato P, Carrilho Paulo Eduardo Mestrinelli, Arruda Walter O, Lorenzoni Paulo J, Scola Rosana H, Werneck Lineu César, Teive Hélio A G
Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba PR, Brazil.
Arq Neuropsiquiatr. 2012 Sep;70(9):657-61. doi: 10.1590/s0004-282x2012000900002.
Neurological disorders associated with glutamic acid decarboxylase (GAD) antibodies are rare pleomorphic diseases of uncertain cause, of which stiff-person syndrome (SPS) is the best-known. Here, we described nine consecutive cases of neurological disorders associated with anti-GAD, including nine patients with SPS and three cases with cerebellar ataxia. Additionally, four had hypothyroidism, three epilepsy, two diabetes mellitus and two axial myoclonus.
与谷氨酸脱羧酶（GAD）抗体相关的神经系统疾病是原因不明的罕见多形性疾病，其中僵人综合征（SPS）最为人所知。在此，我们描述了9例连续的与抗GAD相关的神经系统疾病病例，包括9例SPS患者和3例小脑共济失调病例。此外，4例有甲状腺功能减退，3例有癫痫，2例有糖尿病，2例有轴索性肌阵挛。
