MTHFR C677T 多态性与欧亚大陆紫外线辐射有关吗？

Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?

机构信息

Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science, Peking University, Beijing, China.

出版信息

J Hum Genet. 2012 Dec;57(12):780-6. doi: 10.1038/jhg.2012.113. Epub 2012 Sep 20.

DOI:10.1038/jhg.2012.113

PMID:22992775

Abstract

The methylenetetrahydrofolic acid reductase (MTHFR) C677T polymorphism causes an amino-acid change from alanine to valine and results in the enzyme becoming thermolabile and half decreased activity. Its prevalence varies among global population. We collected data about MTHFR C677T polymorphism prevalence from epidemiology studies, as well as ultraviolet (UV) radiations and some other climatological factors from the internet. The results of the correlation and quadric regression showed that there was inverse U-shape relationship between T allele frequency and UV radiation. The explanatory power of UV radiation was stronger than latitude and all climatological factors. Our results supported the hypothesis that the distribution pattern of MTFHR C677T polymorphism in Eurasia might be the result of interaction of genetic and environmental natural selection, especially the UV radiation.

摘要

亚甲基四氢叶酸还原酶（MTHFR）C677T 多态性导致丙氨酸到缬氨酸的氨基酸变化，从而使酶变得热敏和活性减半。其普遍性在全球人群中有所不同。我们从流行病学研究中收集了有关 MTHFR C677T 多态性流行率的数据，以及来自互联网的紫外线（UV）辐射和其他一些气候因素的数据。相关性和二次回归的结果表明，T 等位基因频率与 UV 辐射之间存在反 U 形关系。UV 辐射的解释力强于纬度和所有气候因素。我们的结果支持这样一种假设，即在欧亚大陆 MTFHR C677T 多态性的分布模式可能是遗传和环境自然选择相互作用的结果，特别是紫外线辐射的结果。