Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), University of Zürich, Zürich, Switzerland.
High Alt Med Biol. 2012 Sep;13(3):176-84. doi: 10.1089/ham.2012.1046.
Hypoxia of the placenta is integral to complications of pregnancy, including preeclampsia, intrauterine growth restriction, and small-for-gestational age babies. Hypoxia in the placenta is associated with vascular remodeling, hypertension, metabolic changes, oxidative stress, mitochondrial dysfunction, and endoplasmic reticular stress. Hypoxia induces similar outcomes in other organs such as the lungs, kidney, and gut. Comparing and contrasting the effects of hypoxia on placental functions and functions of lung, kidney, and gut can lead to novel hypotheses and investigations, furthering our understanding of the impact of hypoxia on these diverse yet similar organs. In this review, we compare and contrast hypoxic placental responses to those in the other organ and cell systems.
胎盘缺氧是妊娠并发症的重要因素，包括子痫前期、宫内生长受限和小于胎龄儿。胎盘缺氧与血管重塑、高血压、代谢变化、氧化应激、线粒体功能障碍和内质网应激有关。缺氧在肺部、肾脏和肠道等其他器官也会引起类似的后果。比较和对比缺氧对胎盘功能和肺、肾和肠道功能的影响，可以产生新的假设和研究，进一步加深我们对缺氧对这些不同但相似器官的影响的理解。在这篇综述中，我们比较和对比了缺氧胎盘反应与其他器官和细胞系统的反应。
