Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Dig Dis Sci. 2013 Mar;58(3):613-20. doi: 10.1007/s10620-012-2383-1. Epub 2012 Sep 22.
Eosinophilic esophagitis (EoE) is a relatively new entity with a significant amount of increased recognition over the last decade. The mainstay treatments of EoE are designed to eliminate the causative allergens or to reduce their effects on the esophageal mucosa. Common treatments include dietary modification, proton pump inhibitors, systemic and topical corticosteroids, and endoscopic treatments. As the pathogenesis of EoE is explored, new and novel treatments are being studied that target specific pathways and chemokines identified in as precipitating agents of EoE. This is a rapidly evolving field with significant ongoing research and clinical studies. Our review will therefore focus on current and novel treatment approaches to the disease.
嗜酸粒细胞性食管炎(EoE)是一种相对较新的疾病实体,在过去十年中得到了广泛的认识。EoE 的主要治疗方法旨在消除致病过敏原或减少其对食管黏膜的影响。常见的治疗方法包括饮食调整、质子泵抑制剂、全身和局部皮质类固醇以及内镜治疗。随着对 EoE 发病机制的探索,针对作为 EoE 诱发剂的特定途径和趋化因子的新型治疗方法正在研究中。这是一个快速发展的领域,有大量正在进行的研究和临床研究。因此,我们的综述将重点介绍该疾病的现有和新型治疗方法。