含有交替 L-Leu-D-Leu-Aib 片段的环状六肽的扭曲结构。

Twisted structure of a cyclic hexapeptide containing a combination of alternating L-Leu-D-Leu-Aib segments.

机构信息

Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158-8501, Japan.

出版信息

J Org Chem. 2012 Oct 19;77(20):9361-5. doi: 10.1021/jo301509c. Epub 2012 Oct 3.

Abstract

We designed and synthesized a C(2)-symmetric cyclic hexapeptide, cyclo(L-Leu-D-Leu-Aib)(2) (2), which contains L- and D-amino acids and achiral Aib residues. The conformation of 2 was analyzed in the crystalline state and in solution, which was a unique figure-eight-shaped conformation.

摘要

我们设计并合成了一个 C(2)-对称的环状六肽，cyclo(L-Leu-D-Leu-Aib)(2) (2)，其中包含 L-和 D-氨基酸和非手性 Aib 残基。2 的构象在晶体状态和溶液中进行了分析，呈现出独特的 8 字形构象。