Campbell Jerry L, Clewell Rebecca A, Gentry P Robinan, Andersen Melvin E, Clewell Harvey J
The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA.
Methods Mol Biol. 2012;929:439-99. doi: 10.1007/978-1-62703-050-2_18.
Physiologically based pharmacokinetic (PBPK) models differ from conventional compartmental pharmacokinetic models in that they are based to a large extent on the actual physiology of the organism. The application of pharmacokinetics to toxicology or risk assessment requires that the toxic effects in a particular tissue are related in some way to the concentration time course of an active form of the substance in that tissue. The motivation for applying pharmacokinetics is the expectation that the observed effects of a chemical will be more simply and directly related to a measure of target tissue exposure than to a measure of administered dose. The goal of this work is to provide the reader with an understanding of PBPK modeling and its utility as well as the procedures used in the development and implementation of a model to chemical safety assessment using the styrene PBPK model as an example.
基于生理的药代动力学（PBPK）模型与传统的房室药代动力学模型不同，因为它们在很大程度上基于生物体的实际生理学。将药代动力学应用于毒理学或风险评估要求特定组织中的毒性效应以某种方式与该组织中物质活性形式的浓度-时间过程相关。应用药代动力学的动机在于期望观察到的化学物质效应与靶组织暴露量的度量比与给药剂量的度量更简单、直接相关。这项工作的目标是通过以苯乙烯PBPK模型为例，让读者了解PBPK建模及其效用，以及在开发和实施用于化学安全评估的模型时所使用的程序。
