桑特 75 衍生物的合成与表征及其作为 Hedgehog 通路抑制剂的研究。

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors.

机构信息

Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China ; Shenzhen Shengjie Biotech Co., Ltd., Shenzhen 518055, China.

出版信息

Beilstein J Org Chem. 2012;8:841-9. doi: 10.3762/bjoc.8.94. Epub 2012 Jun 6.

DOI:10.3762/bjoc.8.94

PMID:23015832

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3388872/

Abstract

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors.

摘要

Sant-75 是一种新鉴定的 hedgehog 通路强效抑制剂。我们设计了一个多样性导向合成计划，并合成了一系列 Sant-75 类似物，为进一步研究这一类重要的 hedgehog 通路抑制剂的构效关系奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1643/3388872/066dac242eb8/Beilstein_J_Org_Chem-08-841-g002.jpg

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桑特 75 衍生物的合成与表征及其作为 Hedgehog 通路抑制剂的研究。

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors.

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桑特 75 衍生物的合成与表征及其作为 Hedgehog 通路抑制剂的研究。

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors.

机构信息

出版信息

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