Tang Deping, Mao Aihong
The School of Chemical & Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2012 Aug;29(4):775-9.
RNA interference (RNAi) is a powerful endogenous process initiated by short double stranded RNAs, which results in sequence-specific posttranscriptional gene silencing. Because any protein that causes or contributes to a disease is susceptible to RNAi, the RNAi has high potential for therapeutic treatments. In a clinical setting, however, there are many obstacles to targeted delivery of small interfering RNA (siRNA) in vivo, specificity and stability of the RNAi reagents. In this review, we focus on recent progress in the development of efficient siRNA delivery vehicles to help the application of siRNA to in vivo therapy.
RNA干扰（RNAi）是一种由短双链RNA引发的强大内源性过程，可导致序列特异性的转录后基因沉默。由于任何导致或促成疾病的蛋白质都易受RNAi影响，因此RNAi在治疗方面具有很高的潜力。然而，在临床环境中，将小干扰RNA（siRNA）体内靶向递送存在许多障碍，包括RNAi试剂的特异性和稳定性。在本综述中，我们重点关注高效siRNA递送载体开发的最新进展，以推动siRNA在体内治疗中的应用。
