Department of Psychology, Centre for the Study of Human Cognition, 0317 Oslo, Norway.
Cogn Emot. 2013;27(3):465-73. doi: 10.1080/02699931.2012.726213. Epub 2012 Sep 27.
Down regulation of serotonin transporter (5-HTT) expression has been associated with brain function and major depression. The aim of this study was to explore the allelic variation (short and long) of the 5-HTTLPR polymorphism in attention bias associated with top-down processing of emotion. One hundred sixty-two healthy participants underwent genotyping (5-HTTLPR), background interviews, psychological screening, and a computerised test session (The Emo 1-back task). Carriers of the short 5-HTTLPR alleles in the serotonin transporter gene (SLC6A4) demonstrated less accuracy in The Emo 1-back task when presented with successive images of sad or fearful faces, but not for happy or neutral emotional faces. The study suggests an association between 5-HTTLPR variation in the serotonin transporter gene and altered emotion processing.
5-羟色胺转运体（5-HTT）表达的下调与大脑功能和重度抑郁症有关。本研究旨在探讨 5-HTTLPR 多态性的等位基因变异（短型和长型）与情绪的自上而下加工相关的注意偏向之间的关系。162 名健康参与者接受了基因分型（5-HTTLPR）、背景访谈、心理筛查和计算机测试（Emo 1-back 任务）。在呈现悲伤或恐惧面孔的连续图像时，5-羟色胺转运体基因（SLC6A4）的短 5-HTTLPR 等位基因携带者在 Emo 1-back 任务中的准确性较低，但对快乐或中性情绪面孔则不然。该研究表明 5-羟色胺转运体基因中的 5-HTTLPR 变异与情绪处理的改变有关。
