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[炎症性肠病治疗的疗效、优化及安全性进展]

[Advances in the efficacy, optimization and safety of treatments for inflammatory bowel disease].

作者信息

Chaparro María

机构信息

Servicio de Aparato Digestivo, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IP) y Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.

出版信息

Gastroenterol Hepatol. 2012 Sep;35 Suppl 1:57-67. doi: 10.1016/S0210-5705(12)70035-3.

Abstract

In Digestive Disease Week 2012, numerous studies were presented on the treatment, monitoring and safety of drugs in inflammatory bowel diseases. New indications for previously approved treatments were evaluated, mainly in perianal disease and the prevention of postsurgical recurrence. New data were provided on biological markers that could help in the follow-up of patients with inflammatory bowel disease. Several studies were presented on the safety of thiopurine drugs and anti-tumor necrosis factor (TNF) agents during pregnancy. However, much of the meeting was centered on studies determining levels of anti-TNF agents and antibodies against them, evaluating new techniques with greater accuracy in determining levels of these agents and antibodies against them, their correlation with clinical response and their utility in optimizing the treatment of patients with inflammatory bowel disease.

摘要

在2012年消化系统疾病周上,展示了众多关于炎症性肠病药物治疗、监测及安全性的研究。对先前已批准治疗方法的新适应症进行了评估,主要针对肛周疾病及预防术后复发。提供了关于可帮助炎症性肠病患者随访的生物标志物的新数据。会上还展示了多项关于硫嘌呤类药物和抗肿瘤坏死因子(TNF)制剂在孕期安全性的研究。然而,会议的大部分内容集中在确定抗TNF制剂及其抗体水平的研究上,评估在测定这些制剂及其抗体水平方面具有更高准确性的新技术,它们与临床反应的相关性以及它们在优化炎症性肠病患者治疗中的效用。

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