Blok Janine L, Reesink-Peters Nathalie, Diercks Gilles F H, Reyners An K L, Terra Jorrit B
Universitair Medisch Centrum Groningen, Afd. Dermatologie, Groningen, the Netherlands.
Ned Tijdschr Geneeskd. 2012;156(40):A5391.
Basal cell carcinoma is the most common form of skin cancer. Generally, the prognosis is relatively good and curative surgical treatment is accomplished in the great majority of patients.
Here we report a case that illustrates the natural course of a vulvar basal cell carcinoma. It concerns an 80-year-old woman who was diagnosed with a so-called 'giant' vulvar basal cell carcinoma causing severe destruction of the anogenital anatomy. At the time of diagnosis, haematogenous metastases were strongly suspected and curative therapy was not possible.
This case description illustrates that a basal cell carcinoma can transform into a 'giant' basal cell carcinoma if it is left untreated for many years. 'Giant' basal cell carcinomas carry a significantly higher risk of metastases than basal cell tumours smaller than 5 cm. In addition, 'giant' basal cell carcinoma is associated with higher morbidity and mortality rates.
基底细胞癌是最常见的皮肤癌形式。一般来说，预后相对较好，绝大多数患者可通过手术治愈。
在此我们报告一例说明外阴基底细胞癌自然病程的病例。患者为一名80岁女性，被诊断患有所谓的“巨大”外阴基底细胞癌，导致肛门生殖器解剖结构严重破坏。诊断时，强烈怀疑有血行转移，无法进行根治性治疗。
本病例描述表明，基底细胞癌如果多年不治疗可转变为“巨大”基底细胞癌。“巨大”基底细胞癌发生转移的风险明显高于直径小于5厘米的基底细胞瘤。此外，“巨大”基底细胞癌的发病率和死亡率更高。
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