5例肾嗜酸细胞瘤中3号染色体短臂的分子分析
Molecular analysis of the short arm of chromosome 3 in five renal oncocytomas.
作者信息
Brauch H, Tory K, Linehan W M, Weaver D J, Lovell M A, Zbar B
机构信息
Laboratory of Immunobiology, National Cancer Institute-Frederick Cancer Research Facility, Maryland 21701.
出版信息
J Urol. 1990 Mar;143(3):622-4. doi: 10.1016/s0022-5347(17)40042-5.
PMID:2304183
Abstract
Renal oncocytomas were tested for loss of alleles at loci on the short arm of chromosome 3, a genetic change characteristic of human renal cell carcinoma. Five renal oncocytomas did not show loss of alleles at loci on 3p supporting the view that renal oncocytoma is a distinct form of renal neoplasia.
摘要
对肾嗜酸细胞瘤进行检测，以确定其3号染色体短臂上基因座的等位基因缺失情况，这是人类肾细胞癌的一种特征性基因变化。五个肾嗜酸细胞瘤在3p上的基因座未显示等位基因缺失，这支持了肾嗜酸细胞瘤是一种独特的肾肿瘤类型的观点。
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