一种针对阿尔茨海默病的保护性突变？
A protective mutation against Alzheimer disease?
作者信息
Proft Juliane, Weiss Norbert
机构信息
Hotchkiss Brain Institute; Department of Clinical Neuroscience; Calgary, AB Canada.
出版信息
Commun Integr Biol. 2012 Jul 1;5(4):301-3. doi: 10.4161/cib.21799.
To date, nearly 35.6 million people world wide live with dementia, and the situation is going to get worse by 2050 with 115.4 million cases.(1) In the western world, the prevalence for dementia in people over the age of 60 is greater than 5% and two thirds are due to Alzheimer disease,(2) (-) (5) the most common form of dementias. Alzheimer disease (AD), first described as "presenile dementia" by the German psychiatrist and neuropathologist Alois Alzheimer in 1906,(6) is a devastating disease characterized by progressive cognitive deterioration, as well as impairments in behavior, language, and visuospatial skills.(7) Furthermore, Alzheimer discovered the presence of intraneuronal tangles and extracellular amyloid plaques in the diseased-damaged brain, the hallmarks of Alzheimer disease.
迄今为止，全球有近3560万人患有痴呆症，到2050年，这一情况将恶化至1.154亿例。（1）在西方世界，60岁以上人群中痴呆症的患病率超过5%，其中三分之二是由阿尔茨海默病导致的，（2）（-）（5）这是最常见的痴呆症形式。阿尔茨海默病（AD）于1906年由德国精神病学家兼神经病理学家阿洛伊斯·阿尔茨海默首次描述为“早老性痴呆症”，（6）是一种具有毁灭性的疾病，其特征是认知功能逐渐衰退，以及行为、语言和视觉空间技能受损。（7）此外，阿尔茨海默发现患病受损大脑中存在神经元内缠结和细胞外淀粉样斑块，这是阿尔茨海默病的标志。
Zotero 插件