2-(7,13-二羟基-2-反式-十八碳烯酰胺基)乙烷磺酸（脂酰牛磺酸）作为牛磺脂生物合成的中间体。
2-(7,13-Dihydroxy-2-trans-octadecenoylamino)ethanesulfonic acid (lipotaurine) as an intermediate of taurolipids biosynthesis.
作者信息
Kaya K, Ito H, Nohara K
机构信息
National Institute for Environmental Studies, Ibaraki, Japan.
出版信息
Biochim Biophys Acta. 1990 Feb 23;1042(3):338-43. doi: 10.1016/0005-2760(90)90162-q.
A hydroxy fatty-acid-combined taurine (lipotaurine) was found in the taurolipids fraction of Tetrahymena thermophila. Lipotaurine accounted for about 1.4% of the total taurolipids of the cells, and was composed of taurine and 7,13-dihydroxy-2-trans-octadecenoic acid. By nuclear magnetic resonance, mass and infrared spectrometries, the chemical structure of lipotaurine was identified as 2-(7,13-dihydroxy-2-trans-octadecenoylamino)ethanesulfonic acid. When cells of T. thermophila were incubated with the double-labeled lipotaurine which was biosynthesized from [2(n)-3H]taurine and [1-14C]stearic acid, both the radioactivities were detected in taurolipid A, B and C. Furthermore, the ratio of the radioactivities of 3H and 14C in the lysotaurolipids were the same as that of the lipotaurine. From these results, it is suggested that lipotaurine is an intermediate of taurolipid biosynthesis.
在嗜热四膜虫的牛磺酸脂组分中发现了一种羟基脂肪酸结合型牛磺酸（脂牛磺酸）。脂牛磺酸占细胞总牛磺酸脂的约1.4%，由牛磺酸和7,13 - 二羟基 - 2 - 反式 - 十八碳烯酸组成。通过核磁共振、质谱和红外光谱法，脂牛磺酸的化学结构被鉴定为2 - (7,13 - 二羟基 - 2 - 反式 - 十八碳烯酰氨基)乙磺酸。当嗜热四膜虫细胞与由[2(n)-³H]牛磺酸和[1 - ¹⁴C]硬脂酸生物合成的双标记脂牛磺酸一起孵育时，在牛磺酸脂A、B和C中均检测到了这两种放射性。此外，溶牛磺酸脂中³H和¹⁴C的放射性比率与脂牛磺酸的相同。从这些结果表明，脂牛磺酸是牛磺酸脂生物合成的中间体。
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