蜕皮激素对发育转变的控制：来自果蝇研究的启示。
Ecdysone control of developmental transitions: lessons from Drosophila research.
机构信息
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA.
出版信息
Annu Rev Entomol. 2013;58:497-516. doi: 10.1146/annurev-ento-120811-153608. Epub 2012 Oct 15.
Abstract
The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent new advances in our understanding of ecdysone action have relied heavily on the application of Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, we focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage- and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signaling.
摘要
蜕皮激素是昆虫发育转变的中央调节剂。我们对蜕皮激素作用的理解最近的新进展主要依赖于应用黑腹果蝇的分子遗传工具来研究昆虫变态。在这篇综述中，我们重点讨论了果蝇蜕皮激素生物学的三个主要方面：（a）调节蜕皮激素释放时间的因素，（b）对蜕皮激素的阶段和组织特异性反应的分子基础，以及（c）蜕皮激素信号的反馈调节和协调。
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