Section of GI Metabolic Surgery; Department of Surgery, Weill Cornell Medical College- New York Presbyterian Hospital, 525 East 68th Street, P-714, New York, NY 10065, USA.
Curr Atheroscler Rep. 2012 Dec;14(6):631-6. doi: 10.1007/s11883-012-0289-1.
It has been observed that bariatric surgery, in addition to its profound weight-reduction effects, leads to a durable resolution of type 2 diabetes. This supports the possibility that a cure for this disease may be obtainable, both by surgery as well as with drugs or devices that mimics the effects of surgery'. Elucidating the mechanisms underlying the beneficial effects of gastrointestinal surgery may also facilitate understanding of the elusive etiology of this condition. Current evidence supports a role for surgical interventions in the treatment algorithm of obese patients with type 2 diabetes, while a number of device-based gastrointestinal interventions are now being investigated as novel and less invasive alternatives. Interventional diabetology could be defined by the use and study of traditional surgical options and novel, gastrointestinal device- based interventions for diabetes. In this manuscript, we discuss how the introduction of interventional diabetology may shape the way we approach diabetes in the 21st century.
已经观察到，减重手术除了具有显著的减肥效果外，还能持久地解决 2 型糖尿病。这支持了这样一种可能性，即通过手术以及模仿手术效果的药物或器械，这种疾病可能得到治愈。阐明胃肠外手术有益效果的机制，也有助于理解这种疾病难以捉摸的病因。目前的证据支持将手术干预纳入肥胖 2 型糖尿病患者的治疗方案，同时，许多基于器械的胃肠干预措施也被作为新颖且微创的替代方法进行研究。介入糖尿病学可以通过使用和研究传统的手术选择以及新颖的、基于胃肠道的器械干预来定义。在本文中，我们讨论了介入糖尿病学的引入将如何塑造我们在 21 世纪对待糖尿病的方式。
