Inserm U682, Université de Strasbourg, Strasbourg, France.
Cell Adh Migr. 2013 Jan-Feb;7(1):90-100. doi: 10.4161/cam.22236. Epub 2012 Oct 17.
Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5) is one of the most widely distributed LM in the developing and mature organism. Its presence in some basement membranes during embryogenesis is absolutely required for maintenance of basement membrane integrity and thus for proper organogenesis. LMα5 also regulates the expression of genes important for major biological processes, in part by repressing or activating signaling pathways, depending upon the physiological context.
层粘连蛋白（LM）是细胞外基质分子，有助于并需要形成基底膜。它们参与调节上皮/间充质相互作用，并参与器官发生和器官稳态的维持。在 LM 分子中，LMα5 链（LMα5）是在发育和成熟的生物体中分布最广泛的 LM 之一。其在胚胎发生过程中存在于某些基底膜中对于维持基底膜完整性以及因此对于适当的器官发生是绝对必需的。LMα5 还通过根据生理情况抑制或激活信号通路来调节对重要生物学过程的基因表达。
