利用三有机铟化合物进行交叉偶联反应合成 4,6-二取代 2-(4-吗啉基)嘧啶。
Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds.
机构信息
Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain.
出版信息
Org Biomol Chem. 2012 Dec 7;10(45):9045-51. doi: 10.1039/c2ob26398j. Epub 2012 Oct 19.
PMID:23080018
Abstract
4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl)pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.
摘要
4,6-二取代-2-(4-吗啉基)嘧啶类化合物是一类重要的生物活性化合物，可通过 4,6-二氯-2-(4-吗啉基)嘧啶与三有机铟试剂进行选择性和顺序钯催化交叉偶联反应来合成。这种方法高效且多功能，允许在 C-4 和 C-6 位置上对各种非对称嘧啶进行功能化。
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