源自M蛋白保守区的嵌合肽对C组和G组链球菌的体内疗效。
In vivo efficacy of a chimeric peptide derived from the conserved region of the M protein against group C and G streptococci.
作者信息
Nordström Therese, Malcolm Jessica, Magor Graham, Good Michael F, Batzloff Michael R
机构信息
Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia.
出版信息
Clin Vaccine Immunol. 2012 Dec;19(12):1984-7. doi: 10.1128/CVI.00140-12. Epub 2012 Oct 17.
Abstract
The J8 peptide from the conserved region of the M protein protects against group A streptococcus infections. In this study, we demonstrate that vaccination with a J8-containing formulation induces IgG that recognizes and binds group C and G streptococci. Moreover, this formulation has the potential to provide protection against infections caused by these organisms.
摘要
来自M蛋白保守区域的J8肽可预防A组链球菌感染。在本研究中，我们证明用含J8的制剂进行疫苗接种可诱导产生识别并结合C组和G组链球菌的IgG。此外，该制剂有潜力预防由这些微生物引起的感染。
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J Clin Microbiol. 2009 Aug;47(8):2502-9. doi: 10.1128/JCM.00312-09. Epub 2009 Jun 10.
2
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PLoS One. 2009;4(4):e5147. doi: 10.1371/journal.pone.0005147. Epub 2009 Apr 2.
3
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J Biol Chem. 2007 Jun 29;282(26):18686-93. doi: 10.1074/jbc.M701047200. Epub 2007 Apr 23.
4
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Microbes Infect. 2005 Jul;7(9-10):1128-38. doi: 10.1016/j.micinf.2005.03.018. Epub 2005 Apr 19.
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J Clin Microbiol. 2004 Nov;42(11):5357-61. doi: 10.1128/JCM.42.11.5357-5361.2004.
6
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Emerg Infect Dis. 2004 Aug;10(8):1455-60. doi: 10.3201/eid1008.030840.
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J Clin Microbiol. 2004 Jan;42(1):186-92. doi: 10.1128/JCM.42.1.186-192.2004.
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Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans.
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