来自 Denham 桃金娘根中的新型茨烯型和愈创木烷型倍半萜。

Novel zierane- and guaiane-type sesquiterpenes from the root of Melicope denhamii.

机构信息

Laboratory of Pharmacognosy, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501 - 1196, Japan.

出版信息

Chem Biodivers. 2012 Oct;9(10):2195-202. doi: 10.1002/cbdv.201100345.

DOI:10.1002/cbdv.201100345

PMID:23081919

Abstract

Two novel zierane-type sesquiterpenes, named melicodenones A and B (1 and 2, resp.), and three new guaiane-type sesquiterpenes, named melicodenones C-E (3-5), were isolated from the root of Melicope denhamii (Seem.) T. G. Hartley together with zierone (6). Their structures were established by extensive NMR-spectroscopic analyses. Compounds 1-6 were tested for cytotoxicity using human colon cancer DLD-1 cells, and melicodenone A (1) was found to exhibit moderate activity.

摘要

从思茅九里香（Melicope denhamii（Seem.）T. G. Hartley）根部分离得到了两个新型紫堇烷型倍半萜，分别命名为 melicodenones A 和 B（1 和 2），以及三个新的愈创木烷型倍半萜，分别命名为 melicodenones C-E（3-5）。通过广泛的 NMR 谱分析确定了它们的结构。测试了化合物 1-6 对人结肠癌细胞 DLD-1 的细胞毒性，发现 melicodenone A（1）具有中等活性。