评估基质金属蛋白酶-1在慢性丙型肝炎患者中标记肝硬化的作用。

Assessment of matrix metalloproteinase-1 for marking liver cirrhosis in chronic hepatitis C patients.

作者信息

Attallah Abdelfattah M, Badr El-Din Nariman K, Omran Mohamed M, Farid Khaled, El-Wahab Ahmed H Abd, El-Bendary Mohamed, El-Dosoky Ibrahim

机构信息

Biotechnology Research Center, New Damietta, Egypt.

出版信息

Egypt J Immunol. 2011;18(1):33-42.

PMID:23082478

Abstract

Our objective in the present study was to observe the change in the serum MMP-1 concentration using ELISA in 129 chronic hepatitis C (CHC) (78 non-cirrhotic and 51 with cirrhotic liver) and 50 healthy controls. The values of MMP-1 concentration increased in patients with CHC according to the stage of liver fibrosis. An area under the ROC curves (AUC) of the MMP-1 was 0.98 for discriminating patients with cirrhotic liver from healthy individuals and was 0.78 for discriminating patients with cirrhotic liver from non cirrhotic patients. The diagnostic potential of MMP-1 for discriminating cirrhosis from healthy individuals was very high with 98% sensitivity and 97% efficiency. MMP-1 detected cirrhosis in CHC with 71% sensitivity and 73% efficiency. In Conclusion, measurement of serum MMP-1 is useful for diagnosing liver cirrhosis in CHC patients.

摘要

我们在本研究中的目的是使用酶联免疫吸附测定法（ELISA）观察129例慢性丙型肝炎（CHC）患者（78例无肝硬化，51例有肝硬化）和50例健康对照者血清基质金属蛋白酶-1（MMP-1）浓度的变化。MMP-1浓度值随肝纤维化阶段在CHC患者中升高。MMP-1的ROC曲线下面积（AUC）在区分肝硬化患者与健康个体时为0.98，在区分肝硬化患者与非肝硬化患者时为0.78。MMP-1区分肝硬化患者与健康个体的诊断潜力非常高，敏感性为98%，效率为97%。MMP-1检测CHC患者肝硬化的敏感性为71%，效率为73%。总之，血清MMP-1的检测有助于诊断CHC患者的肝硬化。