Division of Clinical Neurooncology, Department of Neurology, University Hospital of Bonn, Bonn, Germany.
Expert Rev Neurother. 2012 Oct;12(10):1197-206. doi: 10.1586/ern.12.120.
Primary CNS lymphoma is a high malignant disease of the brain which can lead rapidly to death if diagnosis and/or the start of treatment is delayed. The age at time of diagnosis is a strong factor influencing prognosis so that in younger patients <65 years of age long-term survival may be achieved in a substantial percentage of patients, while in elderly patients long-term survival is seen much more rarely. First-line therapy consists of high-dose methotrexate-based (poly)chemotherapy. This review provides an overview of clinical presentation, steps to diagnosis, detailed information about current treatment concepts and specific information for particular clinical situations.
原发性中枢神经系统淋巴瘤是一种高度恶性的脑部疾病，如果诊断和/或治疗延迟，会迅速导致死亡。诊断时的年龄是影响预后的一个重要因素，因此在年龄较轻的患者(<65 岁)中，相当一部分患者可以实现长期生存，而在老年患者中，长期生存则更为罕见。一线治疗包括大剂量甲氨蝶呤为基础的(联合)化疗。本文综述了原发性中枢神经系统淋巴瘤的临床表现、诊断步骤、当前治疗方案的详细信息以及特殊临床情况下的具体信息。
