松鼠猴（玻利维亚松鼠猴）体内抗缪勒氏管激素的存在：性别和季节差异
Presence of anti-müllerian hormone in the squirrel monkey (Saimiri boliviensis): gender and seasonal differences.
作者信息
Roudebush William E, Nethery R Andrew, Heldreth Todd
机构信息
Department of Biomedical Sciences, University of South Carolina School of Medicine-Greenville, Greenville, SC 29605, USA.
出版信息
J Med Primatol. 2013 Feb;42(1):15-9. doi: 10.1111/jmp.12022. Epub 2012 Oct 22.
BACKGROUND
Anti-mullerian hormone (AMH) is a glycoprotein of the transforming growth factor-β superfamily secreted by male Sertoli cells and female ovarian granulosa cells. This study determined squirrel monkey AMH levels as influenced by gender and seasonality.
METHODS
Squirrel monkey sera AMH were measured by an enzymatically amplified two-site immunoassay.
RESULTS
A significant difference (P<0.001) was found in AMH levels between male (mean=3.46 ng/ml) and female squirrel monkeys (mean=22.12 ng/ml). A significant difference (P<0.05) was found in male AMH levels between breeding (mean=4.21 ng/ml) and non-breeding seasons (mean=2.78 ng/ml). No significant differences were found between female groups.
CONCLUSIONS
Anti-mullerian hormone levels in female squirrel monkeys are the highest in any primate species reported, whereas in the male, levels are within reported ranges. The AMH assay may allow us soon to assess the squirrel monkey fertility potential as a function of various factors.
背景
抗苗勒管激素（AMH）是一种由雄性睾丸支持细胞和雌性卵巢颗粒细胞分泌的转化生长因子-β超家族的糖蛋白。本研究确定了松鼠猴AMH水平受性别和季节性的影响。
方法
采用酶放大双位点免疫分析法测定松鼠猴血清中的AMH。
结果
雄性（平均=3.46 ng/ml）和雌性松鼠猴（平均=22.12 ng/ml）的AMH水平存在显著差异（P<0.001）。雄性松鼠猴在繁殖季节（平均=4.21 ng/ml）和非繁殖季节（平均=2.78 ng/ml）的AMH水平存在显著差异（P<0.05）。雌性组之间未发现显著差异。
结论
雌性松鼠猴的抗苗勒管激素水平在所有报道的灵长类物种中是最高的，而雄性的水平在报道范围内。AMH检测可能使我们很快能够根据各种因素评估松鼠猴的生育潜力。
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