促性腺激素释放激素拮抗剂在宫腔内人工授精周期中的有效性。

Effectiveness of GnRH antagonist in intrauterine insemination cycles.

机构信息

Reproductive Medicine Unit, Christian Medical College Hospital, Vellore 632004, Tamil Nadu, India.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2013 Feb;166(2):168-72. doi: 10.1016/j.ejogrb.2012.09.023. Epub 2012 Oct 18.

DOI:10.1016/j.ejogrb.2012.09.023

PMID:23083636

Abstract

OBJECTIVE

To evaluate the effectiveness of GnRH antagonists in women undergoing controlled ovarian stimulation and intrauterine insemination cycles (COS/IUI).

STUDY DESIGN

Randomized controlled trial. Recruited women were randomized into two groups: GnRH antagonist and control group. The primary outcomes were incidence of premature LH surge and clinical pregnancy rates.

RESULTS

One hundred and forty-one consecutive women were included in the study, with 70 in the antagonist group and 71 in the control arm. The baseline clinical characteristics were similar in both groups. The incidence of premature LH surge and premature luteinization was lower in the antagonist group as compared to the control group (5% vs. 10.3%, P=0.45 and 5% vs. 13.8, P=0.31) but not statistically significant. The clinical pregnancy rates were lower in the antagonist group (2.8% vs. 10%, P=0.12), which was also not statistically significant.

CONCLUSION

The addition of GnRH antagonist during controlled ovarian stimulation and intrauterine insemination cycles does not lead to improvement in clinical pregnancy rates.

摘要

目的

评估 GnRH 拮抗剂在接受控制性卵巢刺激和宫腔内人工授精（COS/IUI）周期的女性中的有效性。

研究设计

随机对照试验。招募的女性被随机分为两组： GnRH 拮抗剂组和对照组。主要结局是早发性 LH 峰的发生率和临床妊娠率。

结果

本研究共纳入 141 例连续女性，拮抗剂组 70 例，对照组 71 例。两组的基线临床特征相似。与对照组相比，拮抗剂组早发性 LH 峰和早发性黄体化的发生率较低（5%比 10.3%，P=0.45 和 5%比 13.8%，P=0.31），但无统计学意义。拮抗剂组的临床妊娠率较低（2.8%比 10%，P=0.12），也无统计学意义。