人类白细胞抗原 DQ2.2 与乳糜泻。
Human leukocyte antigen DQ2.2 and celiac disease.
机构信息
Department of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands.
出版信息
J Pediatr Gastroenterol Nutr. 2013 Apr;56(4):428-30. doi: 10.1097/MPG.0b013e31827913f9.
Patients with celiac disease (CD) lacking both human leukocyte antigen (HLA)-DQ2.5 in cis (DQA105:01, DQB102:01) or trans (DQA105:05, DQB102:02) configuration and HLA-DQ8 (DQA103:01, DQB103:02) are considered to be rare. Therefore, absence of these genotypes is commonly used to exclude the diagnosis of CD. To investigate whether this approach is justified, the HLA-distribution in 155 children with CD was studied. A total of 139 (89.7%) patients carried HLA-DQ2.5. Of the remaining patients, 7 (4.5%) carried HLA-DQ8. Interestingly, the 9 (5.8%) patients lacking HLA-DQ2.5 and HLA-DQ8 carried HLA-DQA102:01 and -DQB102:02 (HLA-DQ2.2). Therefore, HLA-DQ2.2 should be included as an important HLA-type related to CD.
缺乏顺式（DQA105:01，DQB102:01）或反式（DQA105:05，DQB102:02）人类白细胞抗原（HLA）-DQ2.5且不携带 HLA-DQ8（DQA103:01，DQB103:02）的乳糜泻（CD）患者被认为较为罕见。因此，这些基因型的缺失通常用于排除 CD 的诊断。为了研究这种方法是否合理，研究人员研究了 155 名 CD 患儿的 HLA 分布。共有 139 名（89.7%）患者携带 HLA-DQ2.5。其余患者中，有 7 名（4.5%）携带 HLA-DQ8。有趣的是，9 名（5.8%）缺乏 HLA-DQ2.5 和 HLA-DQ8 的患者携带 HLA-DQA102:01 和-DQB102:02（HLA-DQ2.2）。因此，HLA-DQ2.2 应被视为与 CD 相关的重要 HLA 类型。
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