Thiry L
Bull Cancer. 1979;66(4):391-4.
In order to explain why modes of sexual life influence the incidence of cervical carcinoma, several factors have been claimed to be involved. There is no solid basis for the hypothesis that sperm may be mutagenic. By contrast, epidemiological studies showed that partners whose life is not sedentary bring back home to their wives an increased risk of cervical carcinoma. The infectious factor does not seem to be associated with syphilis but may well be represented by herpes genitalis virus (Herpes Simplex type 2 virus). Women with cervical carcinoma show a variety of immunes reactions to this virus, and these reactions are statistically less frequent in control groups. In the laboratory, mouse and hamster cells have been transformed into cancerous cells by means of herpes simplex virus type 2.
为了解释性生活方式为何会影响子宫颈癌的发病率,人们提出了几个相关因素。认为精子可能具有致突变性这一假说并无确凿依据。相比之下,流行病学研究表明,性生活不固定的男性会使其妻子患子宫颈癌的风险增加。感染因素似乎与梅毒无关,但很可能是由生殖器疱疹病毒(单纯疱疹2型病毒)引起的。患有子宫颈癌的女性对这种病毒会表现出多种免疫反应,而且在对照组中,这些反应在统计学上出现的频率较低。在实验室中,通过2型单纯疱疹病毒已将小鼠和仓鼠细胞转化为癌细胞。